Modul EW4110-KP08

Workload:

• 120 Hours private studies
• 90 Hours in-classroom work

Contents of teaching:

• 1. General pharmacology
• 1.1 Pharmacokinetics (LADME model, pharmacokinetic parameters)
• 1.2 Pharmacodynamics (agonism/antagonism, dose-response-relationships, mechanisms of action, receptor types)
• 1.3 Adverse drug reactions (mechanisms, risk factors, pharmacogenetics, kidney and liver injuries, prevention, ADR of herbal supplements)
• 1.4 Drug interactions (mechanisms of drug-drug interactions and food-drug-interactions)
• 1.5 Regulatory affairs of pharmaceuticals (new medications development, phases of clinical studies, approval, pharmacovigilance)
• 2. Specific pharmacology in nutritional medicine
• 2.1 Analgetics (NSAID, opioids, co-analgetics, pharmacotherapy of migraine, local anaesthetics, general anaesthetics)
• 2.2 Gastrointestinal pharmacology (ulcer drugs, helicobacter eradication, CID drugs, laxatives, antidiarrhoeal drugs, antiemetics)
• 2.3 Metabolic pharmacology (pharmacotherapy of diabetes, osteoporosis, obesity, cachexia, gout, dyslipidaemia, pharmacotherapy after bariatric surgery)
• 2.4 Endocrine pharmacology (gluco- and mineralocorticoids, thyroid hormones)
• 2.5 Cardiovascular pharmacology (antihypertensives, diuretics, RAAS inhibitors, adrenoceptor antagonists, calcium antagonists)
• 2.6 Anticoagulants and antiplatelet medication (vitamin K antagonists, NOAC, heparin, clopidogrel, ASS)
• 2.7 Neuropharmacology (antidepressants, antipsychotics, anxiolytics, sedatives, hypnotics)
• 2.8 Antimicrobial pharmacology (mechanisms of action and resistance, antibiotics, antiviral drugs, antifungals)
• 2.9 Antineoplastic pharmacology (mechanisms of action and resistance, chemotherapy, targeted therapies, endocrine therapy, adjuvant pharmacotherapy)
• 3. Pharmaconutrition, nutraceuticals and functional food
• 3.1 Definition and history of immunonutrition
• 3.2 Nutraceuticals and functional food (?3 fatty acids, phytosterols, conjugated linoleic acids (CLA), structured lipids, sphingolipids, prebiotic fibres, prebiotic oligosaccharides, probiotics, folic acid, vitamin E, tocotrienols, calcium, magnesium, iron, selenium, zinc, phytochemicals)
• 3.2 Pharmacological use of nutraceutcials (ICU, oncology, geriatrics, neurology)
• 3.3 Effects of food ingredients and diets on pharmacological drug action (pharmacomicrobiomics, food drug interactions, radio-/chemosensitizer, short-term fasting, fasting mimetics, ketogenic diet)
• 3.4 Effects of food ingredients on pharmacotherapy adverse effects (drug specific supplementation of nutrients)