Module LS4175 B

Module part: Mechanisms of Bacterial Pathogenicity (MedMicroBa)

Duration:

1 Semester

Turnus of offer:

each summer semester

Credit points:

Course of studies, specific field and terms:

Master Infection Biology 2018 (Module part of a compulsory module), Microbiology, 2nd semester
Master Infection Biology 2012 (Module part of a compulsory module), Microbiology, 2nd semester
Master Infection Biology 2023 (Module part of a compulsory module), Microbiology, 2nd semester

Classes and lectures:

Mechanisms of Bacterial Pathogenicity (seminar, 2 SWS)

Workload:

30 Hours in-classroom work
60 Hours private studies

Contents of teaching:

Historical background: Milestones in the discovery of the factors involved in microbial virulence
Invasiveness, toxigenesis, colonization, specific adherence
Structure of bacterial cell membrane, cell wall and cell surface: Gram-positive and Gram-negative bacteria, mycobacteria, virulence factors
Structure and biosynthesis of lipopolysaccharides
Structure and biosynthesis of lipoarabinomannan
Structure, biosynthesis and functions of mycobacterial lipids
Recognition of microbial virulence factors by pattern recognition receptors
Recognition of lipids by immune cells, the role of CD1 presentation
Microbial toxins (e.g., leucocidin, hemolysin, botulinum toxin, diphtheria toxin, anthrax toxin, tetanus toxin, pertussis toxin, cholera enterotoxin, adenylate cyclase, Staphylococcus aureus enterotoxin, TSST, superantigen, shiga toxin, Escherichia coli LT toxin, ST toxin)

Qualification-goals/Competencies:

Competence in critical reading, discussing and presenting research articles
Student can explain structures and biosynthetic pathways of microbial constituents responsible for microbial virulence
Student can explain virulence mechanisms of pathogenic microorganisms
Student can evaluate the quality of experimental data
Student can present a research paper / topic in a seminar setting
Student can conduct literature researches using Pubmed

Grading through:

see Notes

Responsible for this module:

Siehe Hauptmodul

Teachers:

Research Center Borstel, Leibniz Lung Center

Prof. Dr. rer. nat. Otto Holst
Priv.-Doz. Dr. rer. nat. Sven Müller-Loennies

Literature:

n.n.: Provided research articles and own literature research

Language:

offered only in English

Notes:

Is module part of LS4175-KP06

Grading of the module part through
- at least two oral presentations (20 min plus discussion)
- regular in-class assessments
- contribution to discussions
- regular participation in seminars (85%)

Letzte Änderung:

1.11.2020